Juxtapid
Search more drugs→What is Juxtapid?
Juxtapid, known generically as lomitapide, is pronounced as "juk-sta-pid". It belongs to the drug class of microsomal triglyceride transfer protein (MTP) inhibitors. Juxtapid is available by prescription only and is typically administered orally in capsule form. It is specifically designed to lower cholesterol levels in patients with certain genetic conditions.
What conditions or symptoms is Juxtapid used to treat?
Juxtapid is primarily used to treat Homozygous Familial Hypercholesterolemia (HoFH), a rare genetic disorder that results in extremely high cholesterol levels. This condition significantly increases the risk of heart disease at an early age. If you are experiencing symptoms such as chest pain, shortness of breath, or unusual fatigue, please check them here:Check your chest pain, shortness of breath, or fatigue symptoms here.
How does Juxtapid work in the body?
Juxtapid works by inhibiting the microsomal triglyceride transfer protein (MTP), which is essential for the assembly and secretion of lipoproteins in the liver and intestines. By blocking this protein, Juxtapid effectively reduces the production of low-density lipoprotein (LDL) cholesterol, commonly known as "bad" cholesterol, thereby lowering overall cholesterol levels in the bloodstream.
In what forms is Juxtapid available?
Juxtapid is available in capsule form, with various dosage strengths to accommodate different treatment needs. The capsules are designed for oral administration and should be taken whole, without crushing or chewing, to ensure proper absorption and efficacy.
What are the most common side effects of Juxtapid?
- Gastrointestinal symptoms such as diarrhea, nausea, and vomiting
- Abdominal pain and discomfort
- Fatigue and tiredness
- Headache and dizziness
- Increased liver enzymes
What are the serious or severe side effects of Juxtapid?
- Liver damage or hepatotoxicity
- Severe gastrointestinal issues
- Chest pain or palpitations
- Severe allergic reactions, including rash, itching, or swelling
- Unusual bleeding or bruising
How should Juxtapid be stored safely?
Juxtapid should be stored at room temperature, away from direct sunlight and moisture. Keep the medication in its original container, tightly closed, and out of reach of children and pets. Do not store Juxtapid in the bathroom, as the humidity can affect its stability and effectiveness.
What are the overall side effects of Juxtapid?
The overall side effects of Juxtapid include both common and serious reactions. Common side effects are primarily related to the gastrointestinal system, while serious side effects may involve liver function and cardiovascular health. It is crucial to monitor for any unusual symptoms and report them to your healthcare provider promptly.
What warnings or precautions should be considered when taking Juxtapid?
Before starting Juxtapid, it is important to consider potential liver damage, as the medication can significantly affect liver function. Regular liver function tests are recommended to monitor for hepatotoxicity. Additionally, Juxtapid may interact with other medications, so a comprehensive review of your current medications with your healthcare provider is essential.
Who should avoid using Juxtapid?
Juxtapid is not recommended for individuals with moderate to severe liver impairment or those with a history of liver disease. Pregnant or breastfeeding women should avoid using Juxtapid due to potential risks to the fetus or infant. Additionally, individuals with known hypersensitivity to lomitapide or any of its components should not use this medication.
What important information should I know before using Juxtapid?
Before using Juxtapid, it is important to understand the potential risks and benefits of the medication. Discuss any pre-existing medical conditions, especially liver-related issues, with your healthcare provider. Adhering to a low-fat diet is crucial while taking Juxtapid to minimize gastrointestinal side effects and enhance the drug's effectiveness.
What should I discuss with my healthcare provider before starting Juxtapid?
Discuss your full medical history, including any liver conditions, with your healthcare provider before starting Juxtapid. Inform them of all medications, supplements, and herbal products you are currently taking to avoid potential interactions. Additionally, discuss any dietary restrictions or lifestyle changes that may be necessary while on Juxtapid.
Does Juxtapid interact with any foods or beverages?
Juxtapid may interact with certain foods, particularly those high in fat. It is recommended to follow a low-fat diet while taking Juxtapid to reduce the risk of gastrointestinal side effects. Additionally, avoid consuming grapefruit or grapefruit juice, as it can increase the concentration of Juxtapid in the bloodstream, leading to potential toxicity.
Does Juxtapid have interactions with other medications?
Juxtapid can interact with several medications, including certain cholesterol-lowering drugs, anticoagulants, and medications metabolized by the liver. It is essential to provide a complete list of all medications you are taking to your healthcare provider to assess potential interactions and adjust dosages accordingly.
What should I do if I accidentally take too much Juxtapid?
If you accidentally take too much Juxtapid, seek immediate medical attention or contact a poison control center. Overdose symptoms may include severe gastrointestinal distress, liver damage, or other serious health issues. It is crucial to follow the prescribed dosage and consult your healthcare provider if you have any concerns.
What should I do if I miss a dose of Juxtapid?
If you miss a dose of Juxtapid, take it as soon as you remember, unless it is close to the time for your next dose. In such cases, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up, as this may increase the risk of side effects.
What signs or symptoms should I watch for while taking Juxtapid?
While taking Juxtapid, monitor for signs of liver damage, such as yellowing of the skin or eyes, dark urine, or persistent nausea. Additionally, watch for severe gastrointestinal symptoms or any unusual allergic reactions. Report any concerning symptoms to your healthcare provider promptly for further evaluation.
When was Juxtapid first developed and approved by the FDA?
Juxtapid was first developed in the early 2000s and received approval from the U.S. Food and Drug Administration (FDA) in December 2012. It was approved as a treatment for Homozygous Familial Hypercholesterolemia (HoFH), providing a new therapeutic option for patients with this rare and challenging condition.