Verzenio (Abemaciclib)
Search more drugs→What is Verzenio (Abemaciclib)?
Verzenio, generically known as Abemaciclib, is a medication used in the treatment of certain types of breast cancer. It is pronounced as "ver-ZEN-ee-oh" or "a-bem-a-SYE-klib". This drug belongs to the class of medications known as CDK4/6 inhibitors. Verzenio is available by prescription and is typically administered orally in tablet form.
What conditions or symptoms is Verzenio (Abemaciclib) used to treat?
Verzenio is primarily used to treat HR-positive, HER2-negative breast cancer that has spread to other parts of the body. It is often used in combination with other hormone therapies. If you are experiencing symptoms such as persistent fatigue, unexplained weight loss, or changes in breast appearance, it is crucial to seek medical advice. You are having these symptoms, please check them here:Check your persistent fatigue, unexplained weight loss, or changes in breast appearance symptoms here.
How does Verzenio (Abemaciclib) work in the body?
Verzenio works by inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), which are proteins that help control cell division. By blocking these proteins, Verzenio can slow down or stop the growth of cancer cells. This mechanism of action helps in managing the progression of breast cancer, providing a targeted approach to treatment.
In what forms is Verzenio (Abemaciclib) available?
Verzenio is available in tablet form and comes in various dosages to accommodate different treatment regimens. The tablets are designed for oral administration and should be taken as prescribed by a healthcare provider, typically with or without food. It is important to follow the dosage instructions carefully to ensure the effectiveness of the treatment.
What are the most common side effects of Verzenio (Abemaciclib)?
Common side effects of Verzenio include diarrhea, fatigue, nausea, and decreased appetite. Patients may also experience abdominal pain and infections due to a lowered white blood cell count. While these side effects can be bothersome, they are generally manageable with supportive care and should be discussed with a healthcare provider.
What are the serious or severe side effects of Verzenio (Abemaciclib)?
Serious side effects of Verzenio can include severe diarrhea, liver problems, and blood clots. Patients may also experience severe neutropenia, which is a dangerously low level of white blood cells. Immediate medical attention is required if any of these severe side effects occur, as they can lead to more serious health complications.
How should Verzenio (Abemaciclib) be stored safely?
Verzenio should be stored at room temperature, away from moisture and heat. It is important to keep the medication in its original container and out of reach of children and pets. Proper storage ensures the medication remains effective and safe for use throughout its intended shelf life.
What are the overall side effects of Verzenio (Abemaciclib)?
The overall side effects of Verzenio include both common and serious reactions. Common side effects like diarrhea and fatigue are often manageable, while serious side effects such as liver problems and blood clots require immediate medical attention. Patients should be aware of all potential side effects and communicate with their healthcare provider to manage them effectively.
What warnings or precautions should be considered when taking Verzenio (Abemaciclib)?
Patients taking Verzenio should be aware of the risk of severe diarrhea and liver problems. Regular monitoring of liver function and blood cell counts is recommended. It is also important to inform healthcare providers of any other medications being taken to avoid potential drug interactions. Pregnant or breastfeeding women should consult their healthcare provider before starting treatment.
Who should avoid using Verzenio (Abemaciclib)?
Verzenio is not recommended for individuals with severe liver impairment or those who are allergic to any of its components. Pregnant women should avoid using Verzenio due to potential harm to the unborn baby. Patients with a history of blood clots should discuss their condition with a healthcare provider before starting treatment.
What important information should I know before using Verzenio (Abemaciclib)?
Before using Verzenio, it is important to understand the potential side effects and interactions with other medications. Patients should be aware of the signs of serious side effects and seek medical attention if they occur. Regular follow-up appointments with a healthcare provider are essential to monitor the effectiveness and safety of the treatment.
What should I discuss with my healthcare provider before starting Verzenio (Abemaciclib)?
Patients should discuss their complete medical history with their healthcare provider before starting Verzenio. This includes any history of liver disease, blood clots, or other significant health conditions. It is also important to discuss any other medications or supplements being taken to avoid potential interactions.
Does Verzenio (Abemaciclib) interact with any foods or beverages?
Verzenio may interact with certain foods or beverages, particularly those that affect liver enzymes. Grapefruit and grapefruit juice should be avoided as they can increase the levels of Verzenio in the blood, potentially leading to increased side effects. Patients should discuss dietary restrictions with their healthcare provider.
Does Verzenio (Abemaciclib) have interactions with other medications?
Verzenio can interact with a variety of medications, including those that affect liver enzymes such as CYP3A inhibitors and inducers. It is important to inform healthcare providers of all medications being taken to avoid potential interactions. Adjustments to medication regimens may be necessary to ensure safe and effective treatment.
What should I do if I accidentally take too much Verzenio (Abemaciclib)?
In the event of an overdose, it is crucial to seek immediate medical attention. Symptoms of an overdose may include severe diarrhea, vomiting, and signs of liver problems. Prompt medical intervention can help manage symptoms and prevent serious health complications.
What should I do if I miss a dose of Verzenio (Abemaciclib)?
If a dose of Verzenio is missed, it should be taken as soon as remembered unless it is close to the time of the next dose. In such cases, the missed dose should be skipped, and the regular dosing schedule should be resumed. Doubling up on doses to make up for a missed one is not recommended.
What signs or symptoms should I watch for while taking Verzenio (Abemaciclib)?
While taking Verzenio, patients should watch for signs of severe diarrhea, liver problems, and infections. Symptoms such as yellowing of the skin or eyes, severe abdominal pain, or unusual bruising should be reported to a healthcare provider immediately. Regular monitoring and communication with healthcare providers can help manage potential side effects effectively.
When was Verzenio (Abemaciclib) first developed and approved by the FDA?
Verzenio was first developed as part of ongoing research into targeted cancer therapies. It received approval from the U.S. Food and Drug Administration (FDA) in September 2017 for the treatment of HR-positive, HER2-negative advanced or metastatic breast cancer. Since its approval, Verzenio has become an important option in the management of certain breast cancers.