Gocovri.
Search more drugs→What is Gocovri?
Gocovri, pronounced as "go-KOV-ree," is a brand name for the generic drug amantadine. It belongs to the drug class known as adamantanes. Gocovri is available by prescription and is typically administered orally in the form of extended-release capsules.
What conditions or symptoms is Gocovri used to treat?
Gocovri is primarily used to treat dyskinesia in patients with Parkinson's disease who are receiving levodopa-based therapy. It helps manage involuntary movements that can occur as a side effect of Parkinson's treatment. If you are experiencing symptoms such as tremors, stiffness, or balance issues, please check them here:Check your tremors, stiffness, or balance issues symptoms here.
How does Gocovri work in the body?
Gocovri works by modulating the release of dopamine in the brain, which is a crucial neurotransmitter involved in movement control. It acts as an NMDA receptor antagonist, which helps reduce the overactivity of glutamate, a neurotransmitter that can contribute to dyskinesia. This mechanism helps stabilize dopamine levels, thereby improving motor function and reducing involuntary movements in patients with Parkinson's disease.
In what forms is Gocovri available?
Gocovri is available in the form of extended-release capsules, which are designed to be taken once daily. The extended-release formulation allows for a gradual release of the medication into the bloodstream, providing a consistent therapeutic effect over a 24-hour period. This dosage form is convenient for patients as it reduces the frequency of dosing and helps maintain steady drug levels in the body.
What are the most common side effects of Gocovri?
The most common side effects of Gocovri include dizziness, dry mouth, constipation, and swelling of the extremities. Some patients may also experience hallucinations, vivid dreams, or insomnia. These side effects are generally mild and tend to diminish as the body adjusts to the medication. However, if they persist or become bothersome, it is important to consult a healthcare provider.
What are the serious or severe side effects of Gocovri?
Serious side effects of Gocovri can include severe allergic reactions, such as rash, itching, or swelling, particularly of the face, tongue, or throat. Other severe effects may involve changes in mood or behavior, such as depression or suicidal thoughts. In rare cases, Gocovri can cause heart problems, such as arrhythmias. Immediate medical attention is required if any of these symptoms occur.
How should Gocovri be stored safely?
Gocovri should be stored at room temperature, away from moisture and heat. It is important to keep the medication in its original container, tightly closed, and out of reach of children and pets. Do not store Gocovri in the bathroom, as the humidity can affect the integrity of the capsules. Proper storage ensures the medication remains effective until its expiration date.
What are the overall side effects of Gocovri?
Overall, the side effects of Gocovri can range from mild to severe. Common side effects include dizziness, dry mouth, and constipation, while serious side effects may involve allergic reactions and mood changes. Patients should be aware of both the common and severe side effects and report any unusual symptoms to their healthcare provider promptly. Monitoring and communication with a healthcare provider can help manage these side effects effectively.
What warnings or precautions should be considered when taking Gocovri?
Before taking Gocovri, it is important to discuss any history of kidney disease, as dosage adjustments may be necessary. Patients should also inform their healthcare provider of any history of mental health disorders, as Gocovri can exacerbate certain conditions. It is crucial to avoid activities that require alertness, such as driving, until the effects of the medication are known. Alcohol consumption should be limited, as it can increase the risk of side effects.
Who should avoid using Gocovri?
Individuals with known hypersensitivity to amantadine or any of the inactive ingredients in Gocovri should avoid using this medication. Patients with severe renal impairment or those undergoing hemodialysis should not use Gocovri, as it can lead to toxic accumulation. Additionally, pregnant or breastfeeding women should consult their healthcare provider before starting Gocovri, as its safety in these populations has not been fully established.
What important information should I know before using Gocovri?
Before using Gocovri, patients should be aware of the potential for drug interactions and the importance of adhering to the prescribed dosage regimen. It is crucial to inform the healthcare provider of all medications, supplements, and herbal products being taken to avoid adverse interactions. Patients should also be aware of the signs of overdose and the steps to take in such an event. Regular follow-up appointments are important to monitor the medication's effectiveness and adjust the dosage if necessary.
What should I discuss with my healthcare provider before starting Gocovri?
Before starting Gocovri, it is important to discuss any existing medical conditions, such as kidney or liver disease, with your healthcare provider. Patients should also disclose any history of mental health disorders, as Gocovri can affect mood and behavior. It is essential to review all current medications, including over-the-counter drugs and supplements, to prevent potential interactions. Discussing lifestyle factors, such as alcohol consumption and diet, can also help optimize the treatment plan.
Does Gocovri interact with any foods or beverages?
While Gocovri does not have specific food restrictions, it is advisable to take the medication consistently with or without food to maintain stable blood levels. Patients should be cautious with alcohol consumption, as it can enhance the sedative effects of Gocovri and increase the risk of dizziness and drowsiness. It is important to maintain a balanced diet and stay hydrated while on Gocovri to support overall health and well-being.
Does Gocovri have interactions with other medications?
Gocovri can interact with several other medications, including anticholinergic drugs, which can enhance its side effects. It may also interact with other medications used to treat Parkinson's disease, such as levodopa, requiring careful monitoring and dosage adjustments. Patients should inform their healthcare provider of all medications they are taking to avoid adverse interactions. Regular monitoring and communication with the healthcare provider can help manage potential drug interactions effectively.
What should I do if I accidentally take too much Gocovri?
In the event of an overdose, it is crucial to seek immediate medical attention. Symptoms of overdose may include severe dizziness, fainting, or difficulty breathing. Contacting a poison control center or emergency services is recommended. It is important to have information about the amount of Gocovri taken and the time of ingestion available for healthcare professionals to provide appropriate care. Prompt medical intervention can help mitigate the effects of an overdose.
What should I do if I miss a dose of Gocovri?
If a dose of Gocovri is missed, it should be taken as soon as the patient remembers, unless it is close to the time for the next dose. In such cases, the missed dose should be skipped, and the regular dosing schedule should be resumed. Doubling up on doses to make up for a missed dose is not recommended, as it can increase the risk of side effects. Consistency in taking Gocovri is important for optimal management of symptoms.
What signs or symptoms should I watch for while taking Gocovri?
While taking Gocovri, patients should monitor for signs of allergic reactions, such as rash or swelling, and report them to their healthcare provider immediately. It is also important to watch for changes in mood or behavior, such as depression or hallucinations. Any new or worsening symptoms should be discussed with a healthcare provider to determine if adjustments to the treatment plan are necessary. Regular follow-up appointments can help track the medication's effectiveness and safety.
When was Gocovri first developed and approved by the FDA?
Gocovri was first developed as a treatment for dyskinesia in Parkinson's disease patients and received approval from the U.S. Food and Drug Administration (FDA) in 2017. The approval marked a significant advancement in the management of Parkinson's disease, providing an option specifically targeting the involuntary movements associated with long-term levodopa therapy. Since its approval, Gocovri has been an important tool in the therapeutic arsenal for managing Parkinson's disease symptoms.